CTH-JAFAPhos

Synthesis first reported by Jendralla employing stepwise (-)-sparteine mediated enantioselective lithiation/PPh2Cl quench of the precursor diamidoferrocene. There appear to be only two reports in the academic literature of the use of this ligand resulting in >80% ee. [When this ligand was first synthesised only (-)-sparteine was commercially available. Subsequently (-)-sparteine became almost impossible to source. Both enantiomers are now avaialble (at a price) with (+)-sparteine being less expensive.]

C48H54FeN2O2P2_1

Pd – Allylic alkylation OL00-2-629

PP-CTH-JAFAPhos_OL00-2-629

Angew16-55-2526

PP-CTH-JAFAPhos_Angew16-55-2526