The parent ligand 1 was first reported by Schwink and Knochel and was later described as one of a class of FERRIPHOS ligands. Later publications rebranded the following structures differing only in the nature of the phosphorus substituents as MandyPhos ligands. The following lists reactions, organised by metal (Pd, Rh, Ru, Ir, Cu, Ni) for which the application of these ligands has resulted in >80% ee.
Absolute configuration assigned by comparison to data in CEJ09-15-10983. Josiphos-3 has also been applied to this reaction.
Rh – Alkylative ring opening Angew14-53-5951
Ru – Hydrogenation TA04-15-2299
Ir – Transfer hydrogenation CEJ08-14-10388
Absolute configuration assigned by comparison to the result obtained for the reduction under the 1% Ir/ligand conditions of acetophenone [72% ee (S)].
Cu – Beta borylation Angew08-47-145
Similar ee values obtained with Josiphos-1.
Josiphos-1 also applied successfully to this reaction (more examples).
Ni – Lactam C-acylation JACS16-138-8997