Ligands

Many different chiral ligands have been developed for use in metal catalysed asymmetric synthesis, and a significant subset of these are based on ferrocene. These are applicable to numerous reactions, and as such are representative of the wider use of (principally bidentate) phosphine ligand/transition-metal catalysts in asymmetric synthesis. Ferrocene-based ligands available from catalogue suppliers are listed below.

P-N

[Phosferrox]* [PPFA]*

P-S

[FeSulPhos]

1,1′-PP

[CTH-JAFAPhos]* [Mandyphos]* [Chenphos]*

[Trifer]* [Ferrocelane]* [FerroTANE]* [f-Binaphane]

1,2-PP

[BoPhoz]* [Josiphos]* [JoSPOphos]

[Walphos] [Taniaphos]

Other

C₅Ph₅-DMAP

 *Reviews available

P-N Ligands and Catalysts

Phosferrox

C₂₈H₂₈FeNOP – PN-L1a [Review available]

Aldrich (S,S_p)

Strem (S,S_p)* (R,R_p)*

TCI (S,S_p)

[*Suppliers drawn structure does not correspond to configuration given]

 

C₂₉H₃₀FeNOP – PN-L1b [Review available]

Aldrich (S,S_p)

 

C₄₆H₄₃Cl₂FeNOP₂Ru – [(S,S_p)-PN-L1a]RuCl₂(PPh₃) [Review available]

Aldrich (S,S_p) (R,R_p)

Strem (S,S_p) (R,R_p)*

[*Suppliers drawn structure does not correspond to configuration given]

 

PPFA- PN-L2 [Review available]

C₂₆H₂₈FeNP

TCI (R,S_p) (S,R_p)*

[*Suppliers drawn structure does not correspond to configuration given]

 

C₂₅H₂₆FeNP

No longer commercially available

 

C₂₄H₂₄FeNP

Aldrich (S,R_p) (R,S_p)

 

P-S Ligand

FeSulPhos

C₂₆H₂₇FePS

Aldrich (R_p)

 

1,1′-P-P Ligands

CTH-JAFAPhos
C₄₈H₅₄FeN₂O₂P₂ - [Review available]

Alfa (R_p,R_p)

 

C₃₈H₃₇FeNP₂

Aldrich (S,R_p) (R,S_p)

TCI (S,R_p) (R,S_p)

 

Mandyphos

C₅₂H₅₀FeN₂P₂ [Mandyphos-1  review available]

Aldrich (R,R,S_p,S_p)

Strem (R,R,S_p,S_p)

 

C₅₂H₇₄FeN₂P₂ [Mandyphos-2 review available]

Strem (R,R,S_p,S_p)

 

C₆₀H₄₂F₂₄FeN₂P₂ [Mandyphos-3 review available]

Aldrich (R,R,S_p,S_p)

Strem (R,R,S_p,S_p)

 

C₆₄H₇₄FeN₂O₄P₂ [Mandyphos-4 review available]

Aldrich (R,R,S_p,S_p)

Strem (R,R,S_p,S_p)

 

C₆₀H₆₆FeN₂P₂ [Mandyphos-5 review available]

Aldrich (R,R,S_p,S_p)

Strem (S,S,R_p,R_p)* (R,R,S_p,S_p)

[*Suppliers drawn structure does not correspond to configuration given]

Chenphos

C₄₂H₅₃Fe₂NP₂ [Chenphos review available]

Strem (S,R_p,R_phos) (R,S_p,S_phos)

 

Trifer

C₅₀H₅₄Fe₃N₂P₂ [Trifer review available]

Strem bis(S,R_p,R_phos) bis(R,S_p,S_phos)

 

Ferrocelane

C₂₂H₃₂FeP₂ [Me-Ferrocelane] [Review available]

Aldrich (R,R)

Alfa (R,R) (S,S)

Strem (R,R) (S,S)

 

C₂₆H₄₀FeP₂ [Et-Ferrocelane] [Review available]

Aldrich (R,R) (S,S)

Alfa (R,R)

Strem (R,R) (S,S)

 

FerroTANE

C₂₄H₃₆FeP₂ [Et-FerroTANE] [Review available]

No longer available from catalogue suppliers.

 

C₃₂H₄₈BF₄FeP₂Rh [Rh-Et-FerroTANE] [Review available]

No longer available from catalogue suppliers.

 

f-Binaphane

C₅₄H₄₀FeP₂

Strem (S,S)

 

1,2-P-P Ligands

BoPhoz [Review available]

C₃₇H₃₅FeNP₂ [BoPhoz]

Aldrich (S,R_p) (R,S_p)

Strem (S,R_p) (R,S_p)

 

Josiphos

C₃₆H₄₄FeP₂ [Josiphos] [Review available]

Aldrich (S,R_p) (R,S_p)

Strem (S,R_p) (R,S_p)

 

C₂₈H₃₆FeO₂P₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

 

C₃₂H₄₀FeP₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

Strem (S,R_p) (R,S_p)

 

C₃₂H₄₀FeP₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

 

C₃₂H₅₂FeP₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

Strem (R,S_p)

 

C₃₄H₃₂FeO₂P₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

 

C₃₄H₃₈F₆FeP₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

Strem (R,S_p)

 

C₃₄H₄₄FeP₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

 

C₃₄H₄₄FeP₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

 

C₃₆H₃₆FeO₂P₂ [Josiphos type] [Review available]

Aldrich (R,S_p)

Strem (R,S_p)*

[*Suppliers stated configuration does correspond to structure given]

 

C₃₆H₄₄FeP₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

Strem (S,R_p)* (R,S_p)

[*Suppliers drawn structure does not correspond to configuration given]

 

 C₃₆H₅₆FeP₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

Strem (S,R_p) (R,S_p)

 

C₃₈H₅₂FeO₂P₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

 

C₄₀H₄₀FeP₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

Strem (R,S_p)

 

C₄₀H₄₀F₁₂FeP₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

Strem (R,S_p)

 

C₄₀H₄₄FeP₂ [Josiphos type] [Review available]

Aldrich (R,S_p)

 

C₄₂H₅₆FeO₂P₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

Strem (R,S_p)

 

C₄₄H₃₆F₁₂FeP₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

Strem (R,S_p)

 

C₄₄H₄₈FeO₂P₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

 

C₄₆H₅₂FeO₂P₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

 

C₄₈H₄₄FeP₂ [Josiphos type] [Review available]

Aldrich (S,R_p) (R,S_p)

 

JoSPOphos

C₂₆H₃₆FeOP₂ [JoSPOphos type]

Aldrich (S,R_p,S_phos) (R,S_p,R_phos)

Strem (S,R_p,S_phos) (R,S_p,R_phos)

 

C₂₈H₃₂FeOP₂ [JoSPOphos type]

Aldrich (S,R_p,S_phos) (R,S_p,R_phos)

Strem (S,R_p,S_phos) (R,S_p,R_phos)
Walphos

C₄₂H₃₆FeP₂ [Walphos type]

Aldrich (S,S_p) (R,R_p)

Strem (R,R_p)

 

C₄₂H₄₈FeP₂ [Walphos type]

Aldrich (S,S_p) (R,R_p)

Strem (R,R_p)

 

C₄₆H₄₄FeP₂ [Walphos type]

Aldrich (S,S_p) (R,R_p)

Strem (R,R_p)

 

C₄₆H₃₂F₁₂FeP₂ [Walphos type]

Aldrich (S,S_p) (R,R_p)

Strem (R,R_p)

 

C₄₆H₄₄F₁₂FeP₂ [Walphos type]

Aldrich (S,S_p) (R,R_p)

Strem (R,R_p)

 

C₅₀H₅₂FeP₂ [Walphos type]

Aldrich (S,S_p) (R,R_p)

Strem (R,R_p)

 

C₅₂H₄₄F₁₂FeO₂P₂ [Walphos type]

Aldrich (S,S_p) (R,R_p)

Strem (R,R_p)

 

Taniaphos

C₄₃H₃₉FeNP₂ [Taniaphos]

Aldrich (R,R_p) (S,S_p)

Strem (R,R_p)  (S,S_p)

 

C₄₃H₆₃FeNP₂ [Taniaphos type]

Aldrich (R,R_p) (S,S_p)

Strem (R,R_p) (S,S_p)

 

1,2-P-P Catalysts

C₃₂H₅₂Cl₂FeP₂Pd

Aldrich (R,S_p)

Other

C₅H₅-DMAP

C₄₅H₃₆FeN₂

Strem (R_p)